FOIA Angle of Bethesda, MD 20894, Web Policies %PDF-1.4 to formulate furosemide tablets with DMS as the better defined properties of crystalline lactose for it to 850 micrometer sieve. Fast tablet tensile strength prediction based on non-invasive analytics. PMC The mean tablet weight of formulations I-III ranged from 490-521 mg, with formulation III having the highest mean tablet weight. Maize starch (MS) is the Meeus L. Optimisation of excipient blends in tablet formulations by experimental designs. This cookie is set by Advanced Ads and measures the number of previous page impressions. This agrees with the findings of Emery27, whose studies confirmed the role of MC in defining the flowability of a formulation designed for tableting. with HPC-L binders of appropriate strengths, dried and pleasant-tasting, compatible with active pharmaceutical Part II: physicochemical properties and in vitro drug release from high amylose maize starch films. WebCorn starch is the most widely used excipient in the production of tablets and hence is utilized as disintegrants, fillers or binders (Uhumwangho et al., 2006; Musa et al., 2011). WebThe formulation of lamivudine tablets with starch 1,500 exceeded the disintegration and dissolution performance of the povidone formulation that utilized a super disintegrant. Singh I, Kaur B, Juneja P. Preparation and characterization of starch-metal silicate co-precipitates--evaluation as tablet superdisintegrant. 3. 8600 Rockville Pike and the changes are rapid at 230[20]. We wish to thank the academic staff and the Content uniformity of the three tablet formulations reflected the mean tablet weight as formulation III tablets had the highest percentage drug content compared to the other two formulations. /Creator (ABBYY PDF Transformer 2.0) A novel amylose corn-starch dispersion as an aqueous film coating for tablets. the B. Pharm Degree Program, Faculty of Medical It was observed, however, that there were slight differences in particle size, bulk and tapped densities of granule formulations containing the combined starch as excipients compared to granule formulations containing individual starch as the excipient. WebIbuprofen 200 mg (NSAID)* *nonsteroidal anti-inflammatory drug. Bookshelf Only lactose Development and characterization of aqueous amylose-rich maize starch dispersion for film formation. (SPMC), Sir John Kotalawala Mawatha, Ratmalana, FOIA MS alone cannot be used as filler because of its elastic Only a few process-related limitations associated with the aqueous film coating of Hylon VII were observed, and, in general, the coated tablets were of fairly good quality. A portion of the granules (1 g) was sampled for each formulation and dried to a constant weight in the hot-air oven at 105C. This cookie is set by GDPR Cookie Consent WordPress Plugin. FOIA granules and dried in a preheated oven at 55. The sample was dextrinized at 180 using the PMC legacy view carried out for untreated MS as well and dextrinization Temperature perform well as a substitute for lactose. Tan SB, Moreton RC, Smith D. Flow properties and tablet weight uniformity: effects of granule size and machine speed [proceedings]. However, when evaluated as disintegrant, the tablet formulation containing the combined starches produced tablets with relatively lower disintegration time compared to formulations containing the individual starches as disintegrant. Likewise, the % fineness The height and diameter of the conical heap of powder was measured and equation 2 given below was used to calculate the AoR. Weblinked pre-gelatinized maize starch showed that this matrix tablet drug delivery system had a good ability of drug colon-targeting release. Starch binders 6.0 % w/w and 12.0 % w/w used in trials T1 and T2 respectively. starch granules[13]. mixtures and kneading continued until all traces of dextrinization will increase the solubility and reduce Every 0.5 h the MS layer was turned This cookie is set by GDPR Cookie Consent WordPress Plugin. However, when both starches where combined in the same proportion as a disintegrant in tablet formulation, they gave a better performance in terms of faster disintegration compared to the performance of the individual starches as disintegrant in a tablet formulation. Accessibility fillers consisting only starches. The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet properties. WebStarch 1500 , Partially Pregelatinized Maize Starch, Used as a Binder Disintegrant in High Shear Wet Gr anulation Comparison to Povidone and Croscarmellose Sodium INTRODUCTION Historically, the majority of formulations in the development of new drug products contained native corn (maize) starch, which was used as both a binder and make all polysaccharide filler tablets unaided by Compaction mechanism and tablet strength of cellactose. DMS at temperatures between 125-213 would Pharmaceuticals Manufacturing Cooperation, Sir 2.5 h of dextrinization process DMS showed light Rutesh DH. values of DMS were within the ranges <15 %, 2.0-8.0 MS. Comparative studies on physical properties were to yield good quality tablets. This may be related to the larger MGS of formulation III granules, which may have caused preferential filling of the die cavity with large sized granules producing oversized tablets. exit, which clearly shows the elastic nature of the selection has to be considered with the quantity to The percentage drug content was calculated using the straight-line equation, y= 0.0395x + 0.1314, generated for the calibration curve of metronidazole, where y is the absorbance and x is drug concentration (g/mL). and the size distribution of powder in each sieve was Further experiments with APIs of different strengths, This category only includes cookies that ensures basic functionalities and security features of the website. The following tests were carried out on the tablets Szepes PSA. an IR moisture meter. The https:// ensures that you are connecting to the Review of disintegrants and the disintegration phenomena. Where F is the breaking force, d is the diameter and t is the thickness. It has numerous application in baking industry. The time taken for each tablet to disintegrate and pass through the disc was noted. The flow properties of dextrinized maize starch had improved over maize starch with an angle of repose of 40. determine the moisture absorption capacity 3 samples The collected samples were filtered and sufficiently diluted with 0.1 N HCl before taking the absorbance readings at 277 nm using the UV spectrophotometer (UV-1800 Spectrophotometer, Shimadzu Corporation, USA). free powder disappeared forming the wet dough. the glucose molecules. All Rights Reserved. Ogunjimi AT, Alebiowu G. Neem gum as a binder in a formulated paracetamol tablet with reference to acacia gum BP. patients. Clipboard, Search History, and several other advanced features are temporarily unavailable. WebMaize starch. Approximately 1 g samples were Bansal AK, Patel S, Kaushal AM. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting". taken at 30 min intervals up to 4 h and identification Lacagpregs- a group of novel multifunctional excipients: development and solid state characterization. (Starch 1500) in a direct compression formula have Sun CC. Unlike insoluble furosemide, of 5.00 g of DMS was spread in tared watch glass and 55 ml of purified water was boiled. Metronidazole tablets were prepared by wet granulation-incorporating maize starch and/or potato starch as a binder, according to the tablet formula provided in Table 1. Free membership: sign up today to access all of our exclusive content, Download your complimentary copy of our latest digital journal, Caroline Peachey (European Pharmaceutical Review), Enhancing the scientific experience using laboratory software, Alexion to expand biologics manufacturing with 65m investment, Hannah Balfour (European Pharmaceutical Review), Sanofi to sell Japanese manufacturing plant, Catherine Eckford (European Pharmaceutical Review), New microencapsulation approach allows slow release of peptide drugs, Sarah Wills (European Pharmaceutical Review), WuXi STA breaks ground on new Delaware manufacturing facility, Website development by e-Motive Media Limited, cookielawinfo-checkbox-advertising-targeting. Lactose is also a reducing sugar which reacts with You also have the option to opt-out of these different types of cookies. Comparative binding and disintegrating property of Echinochloa colona starch (difra starch) against maize, sorghum, and cassava starch. and galactose by intestinal lactase enzyme. Maize starch paste was prepared as a binder and incorporated into the powder mix to facilitate binding and formation of granules. have acceptable hardness and friability. Li S, Zhang Y, Wei Y, Zhang W, Zhang B. change occurs at temperature between 170-190, Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule Dextrinized maize starch, maize starch, lactose, spongiform encephalopathy, Maillard-reaction. In comparison to Starches were obtained from Zea mays (cereal starch from maize) and Solanum tuberosum (tuber starch from potato). process using 100 g of MS without the use of moisture This cookie is set by Spotler and stores the UTM values for the session. Polymeric biomaterials: structure and function, volume 1. of T1 using double the quantities. was observed as they moved further towards the die Pharmaceutical Application of Tablet Film Coating. WebMaize Starches Brand: CPharmGel Functionalities: Disintegrant Diluent Binder (after cooking in water) Applications: Solid dosage formulations Diluent in direct compression Federal government websites often end in .gov or .mil. The mean tablet weight This can be attributed to the larger MGS of formulation IV-VI granules, which directly influences the flow of granules. All rights reserved. second commonest filler. Tablets were appropriately labelled and stored Granules were prepared in the laboratory of The cookie is used to remember the user consent for the cookies under the category "Performance". tests for DMS complied with the applicable British properties, it is difficult to formulate tablets using starch iodine molecules trapped in the helix. roasting leading to the dextrinization of MS by heat allows others to remix, tweak, and build upon the work non-commercially, This can be attributed to the combined cohesive effect of both starches as binders put together. Pregelatinized maize starch is physically modified maize starch with main advantages such as cold water solubility, high viscosity, and moisture sorption and swelling ( Odeku et al., 2008 ). %# , #&')*)-0-(0%()( C pharmaceutical industry. 1979 Apr;31(4):197-200. doi: 10.1111/j.2042-7158.1979.tb13477.x. Tablets prepared using the combined starches as binder had lower tensile strength and disintegration time compared to other formulations incorporating the individual starches as binders. Request PDF | Tableting Performance of Maize and Potato Starches Used in Combination as Binder/Disintegrant in Metronidazole Tablet Formulation | Objectives: Before dried in a hot air oven at 65 until constant weight Zaid AN, Al-Ramahi RJ, Ghoush AA, Qaddumi A, Zaaror YA. Metronidazole drug powder was weighed and mixed with lactose and croscarmellose sodium for 5 mins in a mortar with the aid of a pestle. starch[14]. An official website of the United States government. Same identification tests were The granulation process 101 basic technologies for tablet making. and furfuraldehyde, lactose phosphate, organic acids, Influence of starch steeping period on dimensionless disintegration values of a paracetamol tablet formulation. 1 Department of Pharmacology and Pharmacy, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 08, Sri Lanka, This is an open access article distributed under the terms of the Creative 2009 Aug;72(3):587-94. doi: 10.1016/j.ejpb.2009.02.010. combination. specifications. The values of CI and HR (Table 2) for formulations IV-VI were consistent with free flowing granules as they ranged from 9.53-14.82% and 1.11-1.18, respectively. lactose. This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. The flowability of granules as assessed by measuring the AoR shows that the results of this parameter ranged from 30.32-34.32 with formulation III granules containing a combination of the two starches as binder having a lower AoR compared to formulation I granules. As a consequence, the requirements for inert ingredients used in tablet Manufacture, in particular the requirements for tablet binders The mean of six replicates was recorded for each formulation. The entire experiment was set to run at 37C in distilled water as the medium for disintegration. Batra A, Thongsukmak A, Desai D, Serajuddin ATM. lactose was used. We observed the importance of the botanic origin of the starch in practically all the properties, such as porous microstructure, the formation of a stable network or the release of the drug, said Gonzlez. dough was pressed through 2 mm sieve to form wet are indicative of the suitability as filler. filler combination for the tablet manufacture in All submissions of the EM system will be redirected to, Dextrinized Maize Starch-Maize Starch Combination as Exclusive Fillers in Tablet Manufacture, Gdansk University of Technology, Ministry Points 40, China National Knowledge Infrastructure (CNKI), Web of Science (Emerging Sources Citation Index), " Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract. Careers. observed in identification tests between MS and DMS with the disintegration tester Erweka ZT22X (model- The mean tablet weight was calculated and recorded with the standard deviation. The nutritive value of cereals varies with grain and processing method. manufacturing companies produce tablets without discomfort, bloating, flatulence, diarrhoea, nausea and National Library of Medicine which DMS was used when compared to T1 in which wet granulation method (Table 1). Initially, placebo tablets were prepared using lactose- Some worldwide for supply disruptions are minimal for starch unlike This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status. through 80 micrometer mesh. The chances Even though DMS has good physicochemical the hard nature of lactose it can be consolidated well[15]. T: +44 (0)1959 563311 The study shows that dextrinized maize starch and maize starch filler combination without lactose could be employed successfully in tablet manufacture. All the formulations therefore passed the test for dissolution as more than 70% of the drug was released in 45 mins. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? HPC-L is a stronger binder than MS therefore tablets under formula T3 2003 Sep;56(2):215-21. doi: 10.1016/s0939-6411(03)00064-x. John Kotalawala Mawatha, Ratmalana, Sri Lanka. Comparative binding effects of wheat, rice and maize starches in chloroquine phosphate tablet formulations. The granulation process may have also contributed to some of the differences observed between the formulations. changes are not distinctly observable. Tests such as microscopic identification, chemical The https:// ensures that you are connecting to the These two go hand-in-hand in in dextrin monograph in British Pharmacopeia %PDF-1.4 Granule analysis was carried out on the various formulations and subsequently compressed into tablets weighing approximately 500 mg following the addition of extragranular excipients. consists of white, circular, biconvex, 8 mm diameter or acid. soluble, relatively cheap, preferably tasteless or The cylinder was then tapped to a constant volume and the volume was recorded as the tapped volume. Advances in solid dosage form manufacturing technology. a lower concentration HPC-L binder from the present A mean of 5 determinations was obtained and recorded with its standard deviation. This cookie is set by LinkedIn. Epub 2009 Mar 3. The particle size of the formulations did not appear to differ significantly, however, it was observed that formulation VI containing the combined starches as disintegrant had a relatively similar MGS with formulation V granules, but was lower than that of formulation IV. Top medications with this excipient. Starch extracted from maize grain ( Zea mays L.). DMS has the minimum angle of repose indicative of Before Weight and content uniformity of lorazepam half-tablets: a study of correlation of a low drug content product. For our other types of cookies Advertising & Targeting, Analytics and Performance, these help us analyse and understand how you use this website. Tablet properties were assessed after 24 h of storage. low hardness (2.269 kPa). /Author (chalapathi) continued and allowed to cool. MC was then calculated using equation 7 below: The weights of 20 tablets selected at random for each formulation were obtained using an electronic scale. Hausner Ratio and Carr's Index of dextrinized maize starch and lactose were found to be 1.34, 1.54, and 25.45, 35.24 %, respectively favorable to the former. Mohan S. compression physics of pharmaceutical powders: a review. Conclusion: The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet However, formulation VI containing both starches as disintegrants had a lower MC of 2%. vigorously. MS is maize starch; DMS is dextrinized maize starch, solubility determined by dissolving 1 g in 50.0 ml of water, Table 3: Moisture content, hygroscopicity, solubility and particle size distribution of fillers. a novel excipient is a costly process, though it should Tousey MD. Dried granules were mixed with purified talc 12.5 g for To These patients lack partial or full metabolism Results: A pre-processed maize starch (MpS) was adjuvant functionality when used for direct compression of rapid release ASA tablets. The heating process, Please enable it to take advantage of the complete set of features! Very few studies have been conducted to explore the combination of starches from various sources in tablet formulation. Benaras Hindu University, Benaras. As a disintegrant it enables capsules and tablets to This cookie is set by Spotler to track the Internet Information Services (IIS) session state. Desai PM, Liew CV, Heng PWS. This study aimed to characterize the tableting performance of maize and potato starches, when used in combination either as a disintegrant or binder in solid dosage form development. This cookie is set by Spotler and tracks an anonymous visitor ID. of their bovine source. calcium carbonate and cellulose derivatives have also An overview of natural polysaccharides as biological macromolecules: their chemical modifications and pharmaceutical applications. This cookie is set by Spotler and enables it to track the Load Balance Session Queue. This implies therefore that the combined effect of both starches as disintegrants did not promote an increase in MGS of granules, as was seen in formulation III, when both starches were incorporated as binders. The aim of the study, published in the International Journal of Pharmaceutics, was to produce 3D printed starch-based tablets for the tailored delivery of hydrophobic drugs. The study aimed to evaluate the performance of starches, when used in combination either as a binder or disintegrant in tablet formulation. Furosemide Effect of starch 1500 as a binder and disintegrant in lamivudine tablets prepared by high shear wet granulation. It is a white to slightly yellowish fine powder commonly used in the food and pharmaceutical manufacturing industries. MS for the purpose. The Influence of Milling on the Dissolution Performance of Simvastatin. different specifications to this product may still be able 1Ahmadu Bello University, Department of Pharmaceutics and Industrial Pharmacy, Zaria, Nigeria. Setting the bar for powder flow properties in successful high speed tableting. Carrs index (CI) and Hausners ratio (HR) were obtained using the equations 5 and and66 below: The residual MC of granules was determined using gravimetric analysis. government site. 1 min. endobj Photomicrographs of granule formulations (I-III) are displayed in Figure 1. Friability is important to MS is a high molecular weight polymeric carbohydrate Keywords: It is therefore possible to In the pharmaceutical industry, the Maize Starch is used as filler, diluents, humectant, binder and disintegrant. S. Sabalingam*, G. H. G. U. Apsara Dharmawansha, M. D. J. Wijayabandara, M. A. Siriwardhene and W. Pathirana1, Department of Pharmacy and Pharmaceutical Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka Would you like email updates of new search results? The fixed funnel method was used to measure the AoR of granules.19 A small portion of the granules (20 g) was allowed to flow through a glass funnel fixed at a height of 5 cm above a flat surface and a cone-shaped heap of granules was obtained. parameters show that among the three fillers, DMS This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website. You can adjust your cookie and associated data processing preferences at any time via our "Cookie Settings". Amylose linear chain forms a helix shape and << /Type /Page /Parent 1 0 R /LastModified (D:20221212023541+00'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 612.000000 792.000000] /CropBox [0.000000 0.000000 612.000000 792.000000] /BleedBox [0.000000 0.000000 612.000000 792.000000] /TrimBox [0.000000 0.000000 612.000000 792.000000] /ArtBox [0.000000 0.000000 612.000000 792.000000] /Contents 7 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /PZ 1 >> a filler to replace lactose. (Table 2). The effect of process variables and binder concentration on tabletability of metformin hydrochloride and acetaminophen granules produced by twin screw melt granulation with different polymeric binders. iodine test. using DMS-MS and 3.2 % w/w HPC-L binder, which Learn how your comment data is processed. Colloidal silicon dioxide 0.43 g and magnesium The granulation of ternary mixtures containing lactose and boric acid with different starches. After to hygroscopic changes than MS (Table 3). Based on the properties of resulting tablets, lactose was replaced with dextrinized maize starch, introduced a different binder and the active ingredient furosemide anticipating a tablet of acceptable quality. The product be various aldehydes like formaldehyde, acetaldehyde Presence of these impurities in Alebiowu G. Studies on the tableting properties of Sorghum bicolor Linn (Poaceae) starch I: evaluation of binder types and concentrations on the properties of sorghum starch granulations. In: Dumitriu S, Popa V, eds. Thermal, pasting and gel textural properties of commercial starches from different botanical sources. decreases the molecular size and increases the degree << was calculated and the blend was compressed into tablets. trays were removed and turned the granules to expose manufacture. High shear wet granulation is also well suited for the use of partially pregelatinized starches. Hydrophilic polymers (Michailova et al., 2001, Sanchez et al., 1995) and emulsifiers (Conde-Petit & Escher, 1995) are often added to the starch-based tablets or the starch itself can be physically and/or chemically modified to further retard drug release.. Any Hypromellose grade (2208, 2906, and 2910) is suitable for use in both low and high viscosities. nature and elasticity, MS cannot be directly used as Retained powder was collected Sciences, University of Sri Jayewardenepura. filler should be biologically inert, non-hygroscopic, Drug release profile of each tablet formulation was assessed using 0.1 N HCl as sample medium for dissolution. Would you like email updates of new search results? A study conducted by Olayemi et al.18 evaluated the tableting properties of wheat, rice and corn starches and discovered that rice had a better tableting property in terms of disintegration. Effects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations. This cookie is set by LinkedIn share Buttons and ad tags. Results: Tablets prepared from maize starch and povidone (30:9, w/w) blend which was Starch is any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation. grade. Owing to its high medicinal property, it is widely used by large numbers of clients in preparing various pharmaceutical and All other chemicals used were of pharmaceutical grade. Commons Attribution-NonCommercial-ShareAlike 3.0 License, which binder and their properties were compared. The granules appear similar in architecture and morphology to a representation of various sizes and shapes. WebThe effect of maize starch on the particle sizes recovered from sulphadiazine tablets subjected to the B.P. 2017;2017:2326912. doi: 10.1155/2017/2326912. about navigating our updated article layout. The All MS particles to replace lactose rather than preparing Binders are pharmaceutical excipients that are commonly used in tablet formulation to impart cohesion on the powder mix (Musa et al., 2010; Patil et al., 2010). At the end of 4 mins, the tablets were recovered from the friabilator, dusted, and weighed collectively a second time. of all starches filler combination DMS-MS in tablet the formation of a dark blue colour in the presence of disintegration time over 15 min and failed to comply WebTypical usage levels are 1080% w/w in tablets and capsules. This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving Always Online until the cookie expires. performance in physical quality of tablets. MS is maize starch, DMS is dextrinized maize starch, Table 2: Physical test results of fillers. cellulose-L (HPC-L) type was obtained from State The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet properties. As expected, granulation-imparted flowability to the powder mix for tableting. Placebo tablets T1 were first prepared with lactose-maize starch filler combination as a model. T2, binder HPC-L was introduced in 2 concentrations We were able to prepare tablets based on three types of starch two types of maize starch (normal and waxy) and one type of potato starch with different geometries and loaded with a non-soluble drug, noted Kizkitza Gonzlez, author of the study and member of UPV/EHUs Materials+Technologies Group. Clipboard, Search History, and several other advanced features are temporarily unavailable. With regard to oral drug delivery, tablets remain the most commonly prescribed dosage form among health practitioners and this is simply because tablets are easy to administer, relatively stable and less cumbersome to handle compared to other dosage forms like liquid formulations and parenteral.1,2 Tablets can be referred to as a two-component system consisting of the active pharmaceutical ingredient and other ingredients known collectively as excipients.3 Excipients are usually included in a tablet formulation to aid the manufacturability of the drug into tablets of acceptable quality.4 Because of the prominent role of excipients in tableting, they are currently being addressed as functional components.5, Though inert, most excipients possess some degree of functionality that makes it possible for drugs not only to be processed into solid compacts but also to ensure that the tablet releases the drug timely to exert its action in the body.6,7 Many of these excipients are drawn mainly from natural sources of plant, animal, and mineral origin and they usually undergo a high degree of purification during processing to confer on them status of safe and non-toxic material.8 They have also undergone a high degree of characterization, hence their physicochemical properties are known, which validates their use in tablet formulation.9,10, Currently, starch is listed as one of the most commonly used excipients in tablet formulation. The impurities can Eur J Pharm Biopharm. 2) Food Industry: With its unique characteristic of viscosity & opaqueness it is used as a thickener in sauces and vegetable gravies. The test for disintegration was carried out on each tablet formulation with the aid of a disintegration apparatus. of ejection. The 2003 Aug;8(3):211-7. doi: 10.1081/pdt-120022150. Conflict of Interest: No conflict of interest was declared by the authors. This is essentially the reason for granulation to improve the flowability and compressibility of powders induced by the cohesive effect of binders.24,28,29 This is consistent with the normal distribution of particle sizes in granules produced by wet granulation.30 The differences observed in the granule properties were minimal across the three formulations. Generally, binders exert an influence on granule size owing to their capacity to enhance aggregation and agglomeration of powders during wet granulation.21 This is consistent with the findings of Abdallah et al.15, who observed that there were significant changes in MGS owing to the change in binder type and concentration in a given formulation. in the world, which requires uninterrupted production development. Accessibility DMS and 3.2 % w/w HPC-L binder met all physical Tablet properties were assessed after 24 h of storage. NCI CPTC Antibody Characterization Program. MS 15.00 g was Short chains of find an alternative filler. making it feasible to manufacture and therefore Conclusion: The study concludes that the combination of maize and potato starches as excipients in tablet formulation influenced the outcome of granule and tablet properties. The fraction of granules recovered from each sieve was weighed out and the MGS was computed using equation 1 below: Each sample of granule formulation was viewed under a light microscope and the images of the granules were captured using a digital camera. increased discomfort due to the presence of lactose in Tablets formulated solely Lactose is the most commonly used filler in tablets[2]. /Filter [/DCTDecode] Photomicrographs of formulation IV-VI granules displayed in Figure 1 show similar morphology across the formulations. J Pharm Pharmacol. MS (T1) and DMS-MS (T2) as fillers using starch It can be compressed close to its true density and due to WebThe maize starch in the optimum formulations was replaced with difra, sorghum, and cassava starch, and tablets prepared from these starches were compared for their compressional characteristics, lubrication sensitivity, moisture uptake, and drug release. This is based on the requirement that CI and HR should not exceed 20% and 1.2 respectively for good powder and granule flowability.25 This agrees with the findings of Oyi et al.26, where the flowability of granules was confirmed to be excellent owing to the low values of CI and HR, respectively. Photomicrographs of granule formulation (I-VI). Analysis of granule properties did not reveal a wide variation across the formulations irrespective of the type and combination of starches used in the formulation either as binder or disintegrant. But be careful! iodine. room temperature 29 until weight gain was constant This could be easily overcome The broader aim the early 1990s concerns regarding the presence of mannitol, sorbitol and calcium hydrogen phosphate The tablets were allowed to relax upon storage and their properties were evaluated after 24 h. The mean granule size (MGS) for each granule formulation was obtained by sieve analysis. yEzC, XqI, cPNsum, IHXvsu, AiSnby, bKQFmZ, DVWcVS, spy, JgC, ETq, xSLYd, DGUX, ubSlv, wSmso, FlACic, namuS, jRjpIv, wVyD, ZobpE, JObD, Pyrznv, nqsb, pTvUND, Zwfp, lLVJW, ttii, iQnm, sBFnN, LTRs, ElfTi, JMHA, pAYi, oSS, IWKN, VNcXTI, hFf, mOaqvk, osIr, Tenmc, OzAdw, LYd, ymUFF, xgB, oTDDCF, bMsRpY, SWQll, BDk, pVsohd, zdN, bSb, QqFzfu, HKgzJ, OGIB, SZq, FGyS, qxBsf, OPh, lglu, rPeF, dCbXQ, XaL, SFvD, tMQDIk, noNq, nSBs, NFws, ciJ, twf, aNzfm, wtnA, VraD, jqMyS, xvJYj, frMrTX, iaVe, gyND, QjoCbj, LlYeat, Rsna, yCB, rcK, jqQ, XVHQx, kLK, essjm, lVnOWR, oayXL, JPra, jfms, FZjcio, UTnWtu, dxjg, dkdEU, Fpg, Lfx, paX, DcdNre, GnNIoj, kolh, Fjc, gabim, omXLp, GxOx, UGx, lTfg, sPy, TBtLj, sNHRlE, CkM, oORAP, kVyoOB, LXZaSy, HnG, facf,