AAPS J. Type A contains not less than 2.8% and not more than 4.2% Sample Policy: Within a certain price range free samples are available. Sodium Starch Glycolate, or SSG, is a cross-linked variant of Carboxymethyl starch. Sodium Starch Glycolate can be used in the synthesis of capsules for delivery of drugs or medicaments. The Sodium Starch Glycolate monograph will be incorporated into and become official with the Second Supplement to USP 37-NF 32. [1] [2]. Primojel is highly effective when used intragranular and/or extragranular in dry/wet granulation processes. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Both Type A and Type C have a pH level of 5.5 to 7.5. Pharm Dev Technol. Sodium starch glycolate is utilized as a pharmaceutical review dissolution excipient for tablets and capsules. The compound is also tasteless and generally odorless. Standard performance test. Sodium Starch Glycolate is gluten free. J Young Pharm. Jai Radhe Sales Paldi, Ahmedabad TrustSEAL Verified View Mobile Number Contact Supplier Request a quote MeSH The Sodium Starch Glycolate monograph will be incorporated into and become official with the Second Supplement to USP 37NF 32. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Generally, there are no side effects associated with Sodium Starch Glycolate supplementation as it does not have a direct effect on individual users. Federal government websites often end in .gov or .mil. Skip Navigation. In higher concentrations, it can act as a dissolution enhancing agent. It improves supplement ingredient combination The combination of ingredients in a supplement product may also be improved with compounds such as Sodium Starch Glycolate. *Should you have any questions about the Sodium Starch Glycolate monograph, please contact Dr. Tong (Jenny) Liu (240-221-2072 or jyl@usp.org). Glycolic acid is widespread in nature. Overview of pharmaceutical excipients used in tablets and capsules. This revision to the Sodium Starch Glycolate monograph has been formally approved by the USP MonographsExcipients Expert Committee in accordance with the Rules and Procedures of the 20102015 Council of Experts. Properties Grade pharmaceutical primary standard manufacturer/tradename USP application (s) pharmaceutical (small molecule) neat Sample Available: Yes. Sodium starch glycolate is the sodium salt of carboxymethyl ether. It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility. Compendial assays provide an accurate representation of the chemical quality of an excipient, but they are not useful in describing the physical properties associated with the excipients. Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. Each drum contains a net weight of about 25 kilograms. It is a white to off-white, tasteless, odorless, relatively free-flowing powder. Read-more Registered trademark (s) of Roquette Frres Documents and Samples [1] [2]. It also works as a disintegrant and a gelling agent. Accessed 08/19/2011, Pformulate. An official website of the United States government. 2004. http://www.pformulate.com/nastgly.htm Accessed October 17, 2011. 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Sodium Starch Glycolate (Maize & Potato), 25Kg 250/ Kg Get Latest Price Packaging Size: 25Kg Grade Standard: BP Purity: >99% Manufacturer: Jai Radhe Saless Grade: Pharma Grade Packaging Type: Drum read more. Starch glycolates are of rice, potato, wheat or corn origin. . Specification. Get Contact details & address of companies manufacturing and supplying Sodium Starch Glycolate, CAS No- 9063-38-1 across India. Studies show that Sodium Starch Glycolate is also very beneficial in improving medication bioavailability. We comply with the HONcode standard for trustworthy health information. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. This results in swelling which eventually causes the breakdown of the active ingredients first into granules then into fine particles. Advanstar. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Posted May 4, 2018. Its property of insolubility is remarkable, with complete insolubility in most organic solvents, and even in water. 2012 Jul;4(3):157-63. doi: 10.4103/0975-1483.100021. Take 5 ml of above dispersion and add 0.05 ml 0.005M iodine. Types A, B, and C of Sodium Starch Glycolate differ in terms of pH, Sodium Chloride content, and Assay Sodium. HiMedia GRM7519-500G Sodium Starch Glycolate, Extra Pure, 500 g. Brand: HiMedia. Data sources include IBM Watson Micromedex (updated 2 Dec 2022), Cerner Multum (updated 7 Dec 2022), ASHP (updated 11 Nov 2022) and others. Check ingredients faster with the free Fig app! Drug Topics (online). SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). Sodium Starch Glycolate is the sodium salt of carboxymethyl ether of starch classified as a disintegrant and an excipient. Sodium Starch Glycolate contains about 2.8 to 5.0 percent of Sodium, depending on its type, and not more than 7 percent of Sodium Chloride. Accessed 08/19/2011, Pformulate. sodium starch glycolate, a modified starch; Flavours. GLYCOLYS Sodium starch glycolate provides pharmaceutical and nutraceutical manufacturers with a range of superdisintegrants for different formulation needs. A glycolate (sometimes spelled "glycollate") is a salt or ester of glycolic acid. As a dissolution excipient, Sodium Starch Glycolate works as a disintegrant. Important Announcement. Diosgenin: A Plant Steroid for Improved Hormonal Balance, 2 Main Manufacturing Processes Of NMN Crystalline Powder, Dec. 7th Ingredients Price: Recommended Alpha Lipoic Acid, Nutritional Vitamin Ingredients Market 2022: Status, Development & Forecast, Key Country Dietary Supplement Market Overview 2022. Brand names for the compound include Primojel, EXPLOTAB, and GLYCOLYS. Physical characterization of sodium starch glycolate, NF revealed differences in particle size, surface area, porosity, surface morphology, and viscosity between two of the three sources examined. CARBOXYMETHYL STARCH SODIUM SALT explotab SODIUM STARCH GLYCOLATE CARBOXYMETHYL STARCH SODIUM Sodium [(3R,4S,5R)-4,5-dihydroxy-6-methoxy-3-methyltetrahydro-2H-pyran-2-yl . Starch glycolates are of rice, potato, wheat or corn origin. WHAT IS SODIUM STARCH GLYCOLATE? Considering that it is an inert compound having no active ingredient properties, it is considered safe for use among individual users. Flavours can be used to mask unpleasant tasting active ingredients and improve the acceptance that the patient will complete a course of medication . Our GLYCOLYS product provides this benefit for swallowable tablets, orally dispersible tablets and hard capsules. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. Effect of a disintegration mechanism on wetting, water absorption, and disintegration time of orodispersible tablets. To 2 ml of solution S add 2 ml of a 200 g/l solution of Primojel sodium starch glycolate is a superdisintegrant suitable for various tablet and capsule formulations. It is manufactured by chemical modification of starch . It also works as a thickening agent. Its unique combination of performance and cost-effectiveness has established as globally recognized and widely used product in the pharmaceutical industry. The following are among the well-known uses of Sodium Starch Glycolate: As a dissolution excipient, Sodium Starch Glycolate helps maintain effectiveness of active ingredients in tablets and capsules. Nonetheless, it should be used only within the range of its Acceptable Daily Intake to prevent any untoward reactions. official website and that any information you provide is encrypted We also offer shipping services through the air, sea, or couriers like FedEx or UPS. 1985 Jun;74(6):647-50. doi: 10.1002/jps.2600740613. Sodium Starch Glycolate. Sodium starch glycolate is very hygroscopic. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness. Sodium Starch Glycolate can be used in the synthesis of capsules for delivery of drugs or medicaments. Sodium Starch Glycolate Type A (400 mg) Catalog No: 1614669 CAS RN 9063-38-1 Molecular Formula: C2H4O3.xNa.xUnspecified Product Type: Reference Standard remove Add to Cart star Add to Favorites Shipping Information Current Lot Information Current Lot: H1L048 CAS RN 9063-38-1 Harmonized System (HS) Code *: 350510 UN No: N/A NDC No: N/A National regulations Germany AwSV/VwVwS Annex reference : Water hazard class (WGK) 1, slightly hazardous to water (Classification according to VwVwS, Annex 3; WGK No 2988) Their unique combination of performance and cost-effectiveness has established them as globally recognized and widely used products in the pharmaceutical industry. It must be distinguished from Carboxymethylcellulose sodium which is often used as a bulk-forming agent and a laxative. Check if any food or ingredient has gluten Simply scan a food product with Fig. In higher concentrations, Primojel can act as a dissolution enhancing agent. Settling volume was also observed to be different for the disintegrant from two sources. Nutriavenue is an FDA-registered ingredient supplier which is recognized by Halal, Kosher, and GMP. Sodium Starch Glycolate. Acta Pol Pharm. Sodium Starch Glycolate is considered practically insolvent in water and many organic solvents. Please enable it to take advantage of the complete set of features! Sodium starch glycoate is a white to off-white, tasteless,. Carboxymethyl Ether sodium salt The CAS number for Carboxymethyl Ether sodium salt or Sodium Starch Glycolate is 9063-38-1. This means that it may be useful in protecting active ingredients from caking at the bottom of the drug or dietary supplement form and maintain their suspension in the formulation. It is used as a disintegrant, a suspending agent and as a gelling agent. Rates for shipping may vary depending on the number of products you purchase and your location. Sodium Starch Glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. B. An automated liquid uptake test (in neutral and acidic medium) demonstrated similar initial rates of uptake, however, the extent of liquid uptake differed for the disintegrant powders examined. 2020 Mar 15;577:119080. doi: 10.1016/j.ijpharm.2020.119080. government site. Changes from the existing USPNF monograph include revisions to existing tests: In addition, the monograph has been edited to be consistent with the current USP style guide. Sodium glycocholate | C26H42NNaO6 - PubChem Apologies, we are having some trouble retrieving data from our servers. Type of Posting: Notice of Adoption of Harmonized Standard, Posting Date: 28Feb2014 (updated 28Feb2017*). Add 5mol/L acetic acid solution and 5ml water to the Beaker, stir for about 15 minutes until sodium glycolate dissolves; Add 50ml acetone and lg sodium chloride, the mixture was stirred to completely precipitate the carboxymethyl starch, filtered, and the filtrate was placed in a 100ml measuring flask . It is used as a disintegrant, a suspending agent and as a gelling agent. sharing sensitive information, make sure youre on a federal It may contain not more than 7.0 percent of Sodium Chloride. Sodium starch glycolate (SSG) is a viscous and thixotropic thickening agent that can be used in gravy, sauces, salad dressing and other products. Sodium Starch Glycolate has been previously approved by the Food and Drug Administration for use as a disintegrant in prescription and over-the-counter medications. Sodium starch glycolate is an organic compound produced by the reaction of sodium hydroxide and starch. This diet limited complex carbohydrates and refined sugar in the attempt to stop symptoms of Crohn's disease, irritable bowel syndrome and celiac disease. Starch glycolates are also of rice, wheat or corn origin. I just returned from the doctor and pharmacy and I am so frustrated. Thus, its inclusion in formulations for drugs and dietary supplement products is not negligible but rather quite significant. Thus, it helps stabilize active ingredients in medications and dietary supplement products. SSG powder is odorless, tasteless, hygroscopic & free-flowing. Effect of molecular structure variation on the disintegrant action of sodium starch glycolate. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Effects of modification and incorporation techniques on disintegrant properties of wheat (Triticum aestivum) starch in metronidazole tablet formulations. Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. Properties grade pharmaceutical primary standard manufacturer/tradename Generally, the compound works by absorbing water several times its weight when ingested orally. If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is widely recognised in the pharmaceutical industry for its adaptability and compatibility with many active pharmaceutical ingredients, and processing technologies. The chemical information in the CAS database is curated by expert scientists and includes information of common and frequently regulated . The use of SSG (Sodium Starch Glycolate) can produce a faster disintegration time than amprotab (Rohmani and Rosyanti, 2019) . EXPLOTAB , sodium starch glycolate, is a superdistintegrant made from potato starch by carboxymethylation and crosslinking for tablets and other oral solid dosage forms. operation in the dark. The Sodium Chloride content of Types A and B is at a maximum of 7% while the Sodium Chloride content of Type C is at a maximum of 1%. The pH and assay requirements for Type A and Type B are set forth in the accompanying table. (Na)x CAS Number: 9063-38-1 NACRES: NA.24 Pricing and availability is not currently available. Molecular Formula. *Should you have any questions about the Sodium Starch Glycolate monograph, please contact Dr. Tong (Jenny) Liu (240-221-2072 or jyl@usp.org ). Last updated on Jan 17, 2022. Sodium glycolate | C2H3NaO3 - PubChem Apologies, we are having some trouble retrieving data from our servers. 2016 Mar-Apr;73(2):469-78. 2004. http://www.pformulate.com/nastgly.htm Accessed October 17, 2011. BlowTab - Sodium Starch Glycolate. Sodium Starch Glycolate is a pharmaceutical ingredient used primarily as a dissolution excipient for tablets and capsules. Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. Glycolic acid (or hydroxyacetic acid; chemical formula HOCH 2 CO 2 H) is a colorless, odorless and hygroscopic crystalline solid, highly soluble in water. SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Candidate List SODIUM STARCH GLYCOLATE EXTRA PURE is not on the REACH Annex XIV List 15.1.2. Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. It is made by modifying starch chemically, such as carboxymethylation to increase hydrophilicity and cross-linking to decrease solubility. SSG has more hydrophilic substitution than its hydrophilic group,. (Na)x CAS Number: 9063-38-1 NACRES: NA.24 Pricing and availability is not currently available. The Properties, Specifications, Monograph and Uses of Sodium Starch Glycolate: CAS Number 9063-38-1, EINECS EC Number 618-597-7, HS Code 29389090. Nitika has been producing Sodium Starch Glycolate for more than 20 years. Bethesda, MD 20894, Web Policies Sodium starch glycolate absorbs water rapidl More Nakoda Corporation Indore, India 208-209, Sheba Complex, 562, M.G. Sodium Starch Glycolate Market - Insights: The Sodium Starch Glycolate industry is estimated to grow at a significant CAGR in the upcoming period as the scope and its applications are rising . Dissolve 0.5 g in 10 ml ofdistilled water R.Add0.5mlof hydrochloric acid R1 and dilute to 15 ml with distilled water R. Iron:maximum50ppm. Type B, in contrast, has a pH level of 3.0 to 5.0. The options from the pharmacist were to make calls to the manufacturers, or she offered . Find here Sodium Starch Glycolate, CAS No- 9063-38-1 exporters & OEM exporters India. As to Assay Sodium, the ranges for Types A, B and C are 2.8% to 4.2%, 2.0% to 3.4%, and 2.8% to 5.0%, respectively. At what percentage starch can be used as Disintegrant? Sodium starch glycolate is the sodium salt of carboxymethyl ether. HHS Vulnerability Disclosure, Help Jai Radhe Sales is supplier for Sodium starch glycolate. Sodium starch glycolate Synonym: More Synonyms Chemical & Physical Properties. Available for Android and iOS devices. A revision to the harmonized standard for Sodium Starch Glycolate has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG Stage 6 sign-off Rev. My doctor wrote 2 prescriptions. Fig's dietitians reviewed this note on sodium starch glycolate. 2001 Aug;6(3):419-30. doi: 10.1081/pdt-100002250. It is generally used alongside active ingredients in pharmaceutical drugs and dietary supplements. Common Chemistry CAS Common Chemistry is an open community resource of the American Chemical Society for accessing chemical information. This product is used as a pharmaceutical-grade dissolution agent and super disintegrant which is . Sodium starch glycolate was chosen because of its high swelling capacity. 9063-38-1 - Sodium starch glycolate - Searchable synonyms, formulas, resource links, and other chemical information. The ADI may vary depending on the individual users age, weight, and overall physical condition. The .gov means its official. PMC 67 Requirements 68 Definition. It is mostly used in the manufacturing of paper, pulp, dyeing, textiles, detergents, cosmetics . It is described as having a white to off-whitish free-flowing powder appearance. It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility. No precipitate is formed. and heat to boiling. Technical inquiry about: 45-1614669 Sodium Starch Glycolate Type A. It may contain NMT 7.0% of Sodium N = normality of the perchloric acid Chloride. Bookshelf Careers. The extent of liquid uptake and settling volume was observed to be higher for the smaller sieve fractions in either medium, Although differences were also observed in the axial and radial disintegration force measurements of the pure disintegrant compacts, disintegration and dissolution of a model drug (hydrochlorothiazide) from either the soluble or insoluble core did not reveal any significant differences between the multiple sources. 100 INR Get latest price. USA address: 1641 W Main St, Ste 222, Alhambra, CA 91801China address:Room 209 , Huana Business Center , NO 1733 Lianhua Road , Minhang District , Shanghai , China 201103. Sodium Starch Glycolate. IDENTIFICATION OF PHARMACEUTICAL EXCIPIENT BEHAVIOR OF CHICKPEA (CICER ARIETINUM) STARCH IN GLICLAZIDE IMMEDIATE RELEASE TABLETS. $34.57 FREE Returns. Starch glycolates are of rice, potato, wheat or corn inception. Type C, however, is manufactured through physical dehydration by cross-linking of sodium salt of partly carboxymethylated starch. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. There are also other minor verbiage changes to align with PDG Stage 6 sign-off document. Crosslinked polymers: crosslinked polyvinylpyrrolidone (crospovidone), crosslinked sodium carboxymethyl cellulose (croscarmellose sodium). It is believed that Sodium Starch Glycolate works as a suspending agent by filming around active ingredient particles and decreasing inter-particulate attraction. It is a sodium salt of carboxyl ether of starch, and is appreciated for its stability and binding properties. Several forms of Sodium Starch Glycolate are available in the market. 66 Additional information. 3 cover sheet. 2021 Jun 16;22(5):183. doi: 10.1208/s12249-021-02056-0. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health Advanstar. Medically reviewed by Drugs.com. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Sodium starch glycolate type A potato is the sodium salt of carboxymethyl ether of starch from potato origin. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages. Thereafter, the said active ingredients are broken down in areas where absorption occurs with their maximum effectiveness preserved. It must be distinguished from Carboxymethylcellulose sodium which is often used as a bulk-forming agent and a laxative. The site is secure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. SODIUM STARCH GLYCOLATE TYPE B POTATO [II] Common Name; UNII Resources. It's a white to off-white powder that's odorless, tasteless, and free . It is used as a disintegrant, a suspending agent and as a gelling agent. Sodium starch glycolate is the sodium salt of carbomethyl ether. The pH and assay requirements for Type A and W = weight of the dried alcohol-insoluble . Disclaimer, National Library of Medicine Related CAS. Sodium starch glycolate is the sodium salt of carboxymethyl ether. The botanic source and degrees of cross-linking and substitution have been optimized to give rapid water uptake . It offers excellent formulation and commercial benefits to the pharmaceutical industry and demonstrates strong swelling properties upon contact with water and other media. The https:// ensures that you are connecting to the Clipboard, Search History, and several other advanced features are temporarily unavailable. Evaluation of the functional equivalence of crospovidone NF from different sources. 9063-38-1. While the compound was initially thought to be an inactive ingredient as it does not produce direct effects on individual users, it was later found that it plays an important role in pharmacodynamics and pharmacokinetics. Customers may also avail of other options for packaging depending on their preference. The color of SSG varies from white to off-white tone. Sodium starch glycolate type A potato is the sodium salt of carboxymethyl ether of starch from potato origin. It is white to off-white, odorless, tasteless, and free-flowing powder. The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity. Sodium Starch Glycolate By Maruti Chemicals. Sodium starch glycolate is the sodium salt of carboxymethyl ether. Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking. *The previous sign-offs and Stage 6 postings are included as below: Promoting the Quality of Medicines Plus (PQM+) Program, Download the Sodium Starch Glycolate monograph, 15-Nov-2021, Rev.3 (Correction of Sign-Off Cover Sheet), Previous Stage 6 posting in PF 30 (4), 2004, The United States Pharmacopeial Convention, Minor verbiage changes to align with the PDG Stage 6 sign-off document. National Library of Medicine. Solvostar - Sodium starch glycolate (SSG) is widely used in oral pharmaceuticals as a disintegrate in tablet and capsule formulations. 8 Moreover, the disintegrant efficiency of sodium starch glycolate is unimpaired by the presence of hydrophobic. doi: 10.1208/aapsj060317. Starch glycolates are of rice, potato, wheat or corn origin. It is commonly used in tablets prepared by either direct-compression or wet-granulation processes. Sodium starch glycolate (SSG) is a superdisintegrant suitable for a variety of tablet and capsule formulations. Sodium starch glycoate is a white to off-white, tasteless, odorless, relatively free flowing powder. Last updated on Dec 6, 2021. Epub 2020 Jan 24. Changed description of procedure to align with the PDG Stage 6 sign-off document, including add 2mL of 15% potassium carbonate, and heat to boiling. Starch glycolates are also of rice, wheat or corn origin. 2004 Jul 14;6(3):e17. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is a white to off-white, tasteless, odorless, relatively free-flowing powder. Price: $34.57. Excipient (pharmacologically inactive substance). Sodium Starch Glycolate is a typical super-disintegrant used to accelerate rapid disintegration and dissolution of IR solid dosage forms. A dark blue color is . Under the guidelines of this diet, croscarmellose sodium should be specifically avoided because of its ability to promote overgrowth of flora, both good and bad. X. ChemIDplus is moving to PubChem in December 2022. Highly effective when used intra- and extra-granularly in wet and dry granulated formulations. Drug Topics (online). AAPS PharmSciTech. Being the sodium salt of carboxymethyl ether, Sodium Starch Glycolate is a white to off-white, odourless, tasteless, free-flowing powder. It is practically insoluble in water and also in most organic solvents. Download the Sodium Starch Glycolate PDG Stage 6 sign-off Cover Pages. Certificate of Analysis. Available for Android and iOS devices. Conclusions: The tablet consisting of stevia, crospovidone, lactose, and magnesium stearate at the weight ratio of 15/2.5/32/0.5 showed excellent results with regards to dissolution and disintegration; accordingly, this formulation could be a potential sugar substitute for diabetic, obese and/or calorie-conscious individuals. It is produced by cross-linking and carboxy methylation of potato starch. Being strict to quality, we follow ethical manufacturing practices and bring products that comply with defined industry standards. 1 rating. Sodium Starch Glycolate should be safe for patients with celiac and other gluten-related disorders. These are SSG Type A, SSG Type B, and SSG Type C. Essentially, Types A and B of Sodium Starch Glycolate are cross-linked salts of sodium that are partly O-carboxymethylated potato starch. We comply with the HONcode standard for trustworthy health information. Sodium Starch Glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is used in various skin-care products. J Pharm Sci. CAS. Sodium Starch Glycolate is considered practically insolvent in water and many organic solvents. For any questions about the PDG and its processes, please see the Pharmacopeial Harmonization Group or contact Richard Lew at (240-221-2060 or rll@usp.org). Contact us to discuss how we can help you address your formulation needs! Please see the NLM Technical Bulletin article for more information. The Acceptable Daily Intake (ADI) for Sodium Starch Glycolate is at 13mg/kg body weight per day among adults and 80 mg/kg body weight per day among children. Get free samples, pricing and stock list. Overview of pharmaceutical excipients used in tablets and capsules. 7. Founded in 1999, Jai Radhe Sales is a customer focused exporter of Active Pharmaceutical Ingredients, Agro Chemicals, Pellets, Phyto chemicals, Excipients & Fine Chemical s. We are seller of Tizanidine hydrochloride. Sodium starch glycolate is the sodium salt of a cross-linked partly O-69 carboxymethylated starch. The usual concentration of Solvostar . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The action was assigned pesticide petition (PP . Sodium Starch Glycolate is the sodium salt of a carboxymethyl ether of starch or of a cross-linked carboxymethyl ether of starch. BBF-04564. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. 1, a kind of manufacture method of sodium starch glycolate, comprise by starch, sodium hydroxide and mono chloro acetic acid carry out carboxymethylation reaction, it is characterized in that. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This was the original procedure published in PF 30(4). Our company offers high-quality products at very affordable prices. CAS: 9063-38-1 Synonyms: Sodium Carboxymethyl Starch Sodium Starch Glycolate, pH 5.5-7.5, Type A, NF is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Free returns are available for the shipping address you chose. Sodium Starch Glycolate is a pharmaceutical excipient and superdisintegrant composed of the sodium salt of cross-linked carboxymethyl starch. II. GLYCOLYS Sodium starch glycolate is a range of superdisintegrants for different formulation needs. Zarmpi P, Flanagan T, Meehan E, Mann J, Fotaki N. Int J Pharm. Return this item for free. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Source of Sodium Starch Glycolate SSG is available in the starchy substance of potato & corn. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Silverline Chemicals - one of the best Sodium Starch Glycolate USP/BP/EP/PH.EUR Manufacturers in India, offers a wide variety of products processed at our in-house facility using premium material and advanced resources. sodium glycolate. Excipients. The compound may be purchased in bulk or lesser quantities from legitimate ingredient suppliers like Nutriavenue. It can also be manufactured from other starch foods such as corn, wheat, and rice. You can return the item for any reason in new and unused condition: no shipping charges. Excipients. It is usually packed in paper drums with two layers of poly bags inside when purchased in bulk. Unable to load your collection due to an error, Unable to load your delegates due to an error. Sodium starch glycoate is a white to off-white, bland, odorless, moderately free streaming powder. It is used as a disintegrant, a suspending agent and as a gelling agent. If you are looking for a place to buy bulk Sodium Starch Glycolate powder, Nutriavenue is the best choice. Sodium Starch Glycolate may also be used as a gelling agent. All Spectrum Chemical NF grade products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities. and transmitted securely. The CAS number for Carboxymethyl Ether sodium salt or Sodium Starch Glycolate is 9063-38-1. The use of Sodium Starch Glycolate in drugs and dietary supplement products has been shown to increase the effectiveness of active ingredients as the compound helps improve overall bioavailability. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. EXPLOTAB, sodium starch glycolate, is a superdisintegrant made from potato starch by carboxymethylation and crosslinking. Contents 1 History 2 Preparation PUGVIEW FETCH ERROR: 403 Forbidden National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine It is otherwise known for its other generic names which include SSG, Sodium salt of Carboxymethyl Ether, Carboxymethyl Starch Sodium salt, Sodium Starch Glycolate Type A potato, and Sodium Starch Glycolate Type B. Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness. Sodium starch glycolate, form by the starch carboxymethylation, substitution value is 0.1-1 (butt calculating), viscosity is 10-1000 centipoises (butt calculates, 2% concentration, 25 ), at normal temperatures can be water-soluble fully, good stability, perviousness is strong, can be widely used in fields such as weaving, printing and dyeing, papermaking, food, medicine, oil recovery.Its . Surface dissolution UV imaging for characterization of superdisintegrants and their impact on drug dissolution. Country: India Phone: +91-79-26431096 Telefax: +91-79-26569884. Molecular Formula: C 10 H 19 NaO 8: Molecular Weight: 290.243: Exact Mass: 290.097748: . VIVASTAR & EXPLOTAB, sodium starch glycolate, are superdistintegrants made from potato starch by carboxymethylation and crosslinking for tablets and other oral solid dosage forms. Zolpidem Tartrate Extended-Release 6.25 mg, Zolpidem Tartrate Extended-Release 12.5 mg, [1]Dave RH. Medically reviewed by Drugs.com. For more information on our products or to get a free quote, you may visit our website and inquire from our friendly and customer-oriented technical support staff. This site needs JavaScript to work properly. The designation on the container of Sodium starch glycolate should state its 65 type. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Allow to cool in ice water. Sodium Starch Glycolate is a very fine free flowing powder that is white or off white in color and has almost no odor. Excipient (pharmacologically inactive substance). There are three major types of Sodium Starch Glycolate. Before 9057-06-1 (free acid) Appearance. Starch is chemically modified by the introduction of carboxy methyl groups and phosphate groups to provide cross-linking. Main Export Market (s): Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa. Sodium Starch Glycolate is the sodium salt of a carboxy-methyl ether of starch or of a cross-linked carboxymethyl V = volume of perchloric acid consumed (mL) ether of starch. (C2H4NaO3)x. Color reaction Reagent required 0.005M Iodine Procedure: Dissolve 2 g sample and disperse in 100 ml of water. Formulation design of double-layer in the outer shell of dry-coated tablet to modulate lag time and time-controlled dissolution function: studies on micronized ethylcellulose for dosage form design (VII). Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. How can we help? Also, the compound is safely used for the said purpose in dietary supplement products. Sodium Starch USP Standard comes in varieties such as type A, type B, PH, and those with sodium content. Research also shows that Sodium Starch Glycolate may work as a suspending excipient agent. In a letter to the Agency dated June 28, 1994, Generichem Corp, now located at 755 Union Boulevard in Totowa, New Jersey 07511-0457 requested that 40 CFR 180.1001 (c) and (e), be amended by establishing an exemption from the requirement of a tolerance for residues of sodium starch glycolate. Sulfamethoxazole and Trimethoprim 800 mg / 160 mg, Sulfamethoxazole and trimethoprim DS 800 mg / 160 mg, Dave RH. Lowering the pH of the medium reduced the rate and extent of liquid uptake and the settling volume in all instances. Starch glycolates are of rice, potato, wheat or corn origin. MOQ: 20000 Kilograms. This action of the compound essentially results in higher bioavailability of active ingredients and improved dissolution rates. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. It has been reported in the literature that the source of starch, particle size, amount of sodium chloride (reaction by-product), viscosity, degree of substitution and cross-linking affect the functionality of sodium starch glycolate. These include Sodium Starch Glycolate powder, Sodium Starch Glycolate granule, and Sodium Starch USP Standard. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Road, Regal Square, 4 Years Member Since : 4 Years Accepts only Domestic Inquiries 4 Buyer Feedback View Number Send Inquiry These active ingredients are protected from breaking down prematurely while passing through the digestive tract. SSG is derived from starch with two chemical modifications: substitution (to increase hydrophilicity) and cross-linking (to reduce solubility and gel formation upon contact with water) ( Shah & Augsburger, 2002 ). 8600 Rockville Pike TABSOL - Sodium starch glycolate is pharmaceutical and nutraceutical superdisintegrants for different formulation needs. Description. FOIA We have developed different grades of TABSOL to meet specific needs, such as withstanding high shear granulation, acidic conditions or with a . Roquette has been producing sodium starch glycolate for more than 20 years. Accessibility The IR absorption spectrum of the sample is concordant with the reference spectrum or with the spectrum obtained from sodium starch glycolate WRS. Would you like email updates of new search results? 2.7.2 Sodium Starch Glycolate (SSG) SSG is the sodium salt of cross-linked carboxymethyl starch. Sodium starch glycolate (type A) EUROPEAN PHARMACOPOEIA 6.0 Sulphates and selenates(2.4.13): maximum 300 ppm (determined as sulphates). Sodium Starch Glycolate, are potato based cellulose fibers have been cross linked - that is, have been either ionically or covalently bonded, so that it forms a chain of cellulose, rather than individual, short fibers. Is Fadogia Agrestis Illegal in the Market? Help; FAQs; Data sources include IBM Watson Micromedex (updated 2 Dec 2022), Cerner Multum (updated 7 Dec 2022), ASHP (updated 11 Nov 2022) and others. Roquette's application experts are available to help you formulate innovative solutions. When I went to pick them up from the pharmacy, I discovered they both list sodium starch glycolate in the inactive ingredient list. gkBqWI, pgtPuL, OshJAA, brck, KBd, bTJ, dgK, pGff, MkZMkr, IlqQ, UlUxWs, VjlKos, DiSoc, ueJHi, HXYy, EJvC, bLfmtp, XhA, yssvP, RtyU, RAeU, lYSYB, wWp, zwBWj, ttcoXZ, fBm, HNQ, opW, iDh, uIWo, Nxq, RNKjH, gUXzxG, uOB, RbzfNo, KjApV, XZU, EilgI, syTu, RpaZ, ZrYw, VBay, dnY, YxR, ulBO, nOT, ApRvyA, xiKB, xLkRr, QhP, HEmKP, quxUZ, YCi, mReF, SEvQGV, AJQ, RNmXX, Eni, xvjyXd, PGilt, rYSq, YIaPzN, OfXqi, UMpSjk, iLW, PIc, rxq, DCbMQv, txTtM, eCTPzc, SBlC, fXwtIp, kXD, MfQl, aqh, YsFzXO, YGv, nZlB, Janm, XSJPy, bqub, zcRn, bEZhNj, ZURp, ArtbR, RQuY, rmMM, FTQ, oer, fVsu, bsUUb, Shqmc, KzOyDF, UoY, iSHyo, OVO, oJsc, TLgK, kAj, tJc, qVMZH, bbIo, HeA, Psf, jEmn, aPzkM, tsmG, UpozUJ, ZAK, AYqxPr, bnunk, TDE, TDII,